A*02:01/HIV-1 Vpu (ALVEMGHHA) MHC Tetramer (CAT#: MHC-CN1384)
Specific Inquiry
Specifications
- Allele
- A*02:01
- Class
- Class I
- MHC Species
- Human
- Antigen
- Vpu
- Antigen Species
- HIV-1
- Peptide
- ALVEMGHHA
- Conjugate
- Unconjugated
- Application
- FCM, IHC
Target
- Antigen Introduction
- Enhances virion budding by targeting host CD4 and Tetherin/BST2 to proteasome degradation. Degradation of CD4 prevents any unwanted premature interactions between viral Env and its host receptor CD4 in the endoplasmic reticulum. Degradation of antiretroviral protein Tetherin/BST2 is important for virion budding, as BST2 tethers new viral particles to the host cell membrane. Mechanistically, Vpu bridges either CD4 or BST2 to BTRC, a substrate recognition subunit of the Skp1/Cullin/F-box protein E3 ubiquitin ligase, induces their ubiquitination and subsequent proteasomal degradation. The alteration of the E3 ligase specificity by Vpu seems to promote the degradation of host IKBKB, leading to NF-kappa-B down-regulation and subsequent apoptosis. Ion channel activity has also been suggested, however, formation of cation-selective channel has been reconstituted ex-vivo in lipid bilayers. It is thus unsure that this activity plays a role in vivo.
- Gene ID
- 155945
- UniProt ID
- P05919
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MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN1381 | PE-A*02:01/HIV-1 Vpu (ALVEMGHHA) MHC Tetramer | FCM, IHC | |
| MHC-CN1382 | APC-A*02:01/HIV-1 Vpu (ALVEMGHHA) MHC Tetramer | FCM, IHC | |
| MHC-CN1383 | FITC-A*02:01/HIV-1 Vpu (ALVEMGHHA) MHC Tetramer | FCM, IHC | |
| MHC-YF778 | A*02:01/HIV Vpu (ALVEMGHHA) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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