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A*11:01/HIV Gag p24 (ACQGVGGPGHK) MHC Pentamer (CAT#: MHC-YF449)

MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Gag p24-derived peptide of ACQGVGGPGHK sequence and A*11:01 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.


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Specific Inquiry
  • Size:
  • Datasheet
  • MSDS
  • COA

Specifications

  • Allele
  • A*11:01
  • Class
  • Class I
  • MHC Species
  • Human
  • Antigen
  • Gag p24
  • Antigen Species
  • HIV
  • Peptide
  • ACQGVGGPGHK
  • Conjugate
  • Unlabeled, Biotin, R-PE, APC
  • Application
  • FCM

Target

  • Antigen Introduction
  • Capsid protein p24: Forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. Most core are conical, with only 7% tubular. The core is constituted by capsid protein hexamer subunits. The core is disassembled soon after virion entry. Host restriction factors such as monkey TRIM5-alpha or TRIMCyp bind retroviral capsids and cause premature capsid disassembly, leading to blocks in reverse transcription. Capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species. Host PIN1 apparently facilitates the virion uncoating (By similarity). On the other hand, interactions with PDZD8 or CYPA stabilize the capsid (PubMed:24554657).
  • Alternative Names
  • Gag polyprotein; Pr55Gag; gag; Gag p24, p24

Downloads

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See other products for "Gag p24"

MHC Tetramer for Virology

CAT Product Name Application Type
MHC-YF450 B*08:01/HIV Gag p24 (EIYKRWII) MHC Pentamer FCM
MHC-YF451 B*08:01/HIV Gag p24 (GEIYKRWII) MHC Pentamer FCM
MHC-YF452 B*27:05/HIV Gag p24 (KRWIILGLNK) MHC Pentamer FCM
MHC-YF453 B*27:05/HIV Gag p24 (KRWIIMGLNK) MHC Pentamer FCM
MHC-YF454 H-2Kd/HIV Gag p24 (AMQMLKETI) MHC Pentamer FCM

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For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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