A*24:02/Human Immunodeficiency virus 1 Nef protein (RYPLTFGW) MHC Pentamer (CAT#: MHC-YC168)
MHC multimers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a Pentamer of peptide/MHC complex with HIV-derived peptide of RYPLTFGW sequence covering 134-141 and A*24:02 molecule. The peptide/MHC pentamer provided here is unlabeled or fluorescent labeled such as Biotin, R-PE, APC. And all of them are available in 50, 150 or 500 tests.
Specific Inquiry
Specifications
- Allele
- A*24:02
- Class
- Class I
- Antigen
- Human Immunodeficiency virus 1 Nef protein
- Antigen Species
- HIV
- Peptide
- RYPLTFGW
- Range
- 134-141
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- The expression of Nef early in the viral life cycle ensures T-cell activation and the establishment of a persistent state of infection, two basic attributes of HIV infection. Viral expression of Nef induces numerous changes within the infected cell including the modulation of protein cell surface expression, cytoskeletal remodeling, and signal transduction. Since the activation state of the infected cell plays an important role in the success rate of HIV-1 infection, it is important that resting T-cells be primed to respond to T-cell receptor (TCR) stimuli. HIV-1 Nef lowers the threshold for activation of CD4+ lymphocytes, but is not sufficient to cause activation in the absence of exogenous stimuli.
- Alternative Names
- HIV1gp9; p27
- Gene ID
- 156110
Downloads
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See other products for "HIV Nef"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472 | Recombinant Anti-HIV Nef Antibody | ELISA, WB, FuncS | IgG |
| MHH-472 | Recombinant Human Anti-HIV Nef Antibody | FC, Neut, Biosensors, FuncS | IgG |
| MRO-754CQ | Mouse Anti-HIV Nef Recombinant Antibody (clone AG11) | ELISA, IP, IF, WB | Mouse IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-F(E) | Recombinant Anti-HIV Nef Antibody Fab Fragment | WB, FuncS | Fab |
| MHH-472-F(E) | Recombinant Human Anti-HIV Nef Antibody Fab Fragment | WB, Dot, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-S(P) | Recombinant Anti-HIV Nef Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-472-S(P) | Recombinant Human Anti-HIV Nef Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-022 | Recombinant Anti-HIV-1 nef VHH Single Domain Antibody (sdAb19) | Inhib, WB, FuncS | Llama VHH |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0821 | PE-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0822 | APC-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0823 | FITC-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0824 | A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-YF576 | A*02:01/HIV Nef (LTFGWCFKL) MHC Pentamer | FCM |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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