A*24:02/HIV Nef (RYPLTFGWCF) MHC Pentamer (CAT#: MHC-YF579)
MHC pentamers have a high avidity for CD8 T cells, and can be used in the analysis of individual antigen-specific T cells. This product is a MHC pentamer of peptide/MHC complex composed Nef-derived peptide of RYPLTFGWCF sequence covering 143-152 and A*24:02 molecule. The peptide/MHC pentamer provided here is unlabelled or fluorescent labelled, such as Biotin, R-PE, APC. All products are available in 50, 150 and 500 tests.
Specific Inquiry
Specifications
- Allele
- A*24:02
- Class
- Class I
- Antigen
- Nef
- Antigen Species
- HIV
- Peptide
- RYPLTFGWCF
- Range
- 143-152
- Conjugate
- Unlabeled, Biotin, R-PE, APC
- Application
- FCM
Target
- Antigen Introduction
- Extracellular Nef protein targets CD4+ T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors. Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.
- Alternative Names
- Protein Nef; F-protein; nef
- Gene ID
- 156110
- UniProt ID
- A0EU06
Downloads
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See other products for "HIV Nef"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472 | Recombinant Anti-HIV Nef Antibody | ELISA, WB, FuncS | IgG |
| MHH-472 | Recombinant Human Anti-HIV Nef Antibody | FC, Neut, Biosensors, FuncS | IgG |
| MRO-754CQ | Mouse Anti-HIV Nef Recombinant Antibody (clone AG11) | ELISA, IP, IF, WB | Mouse IgG1, κ |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-F(E) | Recombinant Anti-HIV Nef Antibody Fab Fragment | WB, FuncS | Fab |
| MHH-472-F(E) | Recombinant Human Anti-HIV Nef Antibody Fab Fragment | WB, Dot, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-472-S(P) | Recombinant Anti-HIV Nef Antibody scFv Fragment | IP, IF, Biosensors, FuncS | scFv |
| MHH-472-S(P) | Recombinant Human Anti-HIV Nef Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
Single-domain Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-022 | Recombinant Anti-HIV-1 nef VHH Single Domain Antibody (sdAb19) | Inhib, WB, FuncS | Llama VHH |
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0821 | PE-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0822 | APC-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0823 | FITC-A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-CN0824 | A*11:01/HIV NEF (AVDLSHFLK) MHC Tetramer | FCM, IHC | |
| MHC-YF259 | Mafa-B*104:01/SIV nef LT9 (LNMADKKET) MHC Monomer | MHC Multimer |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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