A*24:02/EBV LMP2 (PYLFWLAAI) MHC Monomer (CAT#: MHC-YF302)
This product is a MHC monomer of biotinylated peptide/MHC complex composed LMP2-derived peptide of PYLFWLAAI sequence covering 131-139 and A*24:02 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- A*24:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- LMP2
- Antigen Species
- EBV
- Peptide
- PYLFWLAAI
- Range
- 131-139
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Isoform LMP2A maintains EBV latent infection of B-lymphocyte, by preventing lytic reactivation of the virus in response to surface immunoglobulin (sIg) cross-linking. Acts like a dominant negative inhibitor of the sIg-associated protein tyrosine kinases, LYN and SYK. Also blocks translocation of the B-cell antigen receptor (BCR) into lipid rafts, preventing the subsequent signaling and accelerated internalization of the BCR upon BCR cross-linking. Serves as a molecular scaffold to recruit SYK, LYN and E3 protein-ubiquitin ligases, such as ITCH and NEDD4L, leading to ubiquitination and potential degradation of both tyrosines kinases. Possesses a constitutive signaling activity in non-transformed cells, inducing bypass of normal B lymphocyte developmental checkpoints allowing immunoglobulin-negative cells to colonize peripheral lymphoid organs.
- Alternative Names
- Latent membrane protein 2, LMP-2A, LMP-2, LMP2
- Gene ID
- 3783751
- UniProt ID
- P13285
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LMP-2A"
MHC Tetramer for Virology
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-YF170 | A*24:02/EBV LMP-2 (TYGPVFMCL) MHC Monomer | MHC Multimer | |
| MHC-YF178 | B*35:01/EBV LMP2 (MGSLEMVPM) MHC Monomer | MHC Multimer | |
| MHC-YF232 | A*02:01/EBV LMP2 (CLGGLLTMV) MHC Monomer | MHC Multimer | |
| MHC-YF290 | A*02:01/EBV LMP-2 (FLYALALLL) MHC Monomer | MHC Multimer | |
| MHC-YF517 | A*02:01/EBV LMP2 (CLGGLLTMV) MHC Pentamer | FCM |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for MHC-YF302. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.