Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein

Anti-ENPP3-mc-MMAF ADC (CAT#: ADC-021LZY)

This ADC product is composed of an anti-ENPP3 antibody conjugated via mc linker to MMAF (anti-ENPP3-mc-MMAF). It is in phase I clinical trials and has demonstrated a response in renal cell carcinoma treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 High expression in seminal vesicle
Figure 1 High expression in seminal vesicle

* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_8_6_val_selected.jpg
Figure 2 Low expression in placenta
Figure 2 Low expression in placenta

* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_1_7_val_selected.jpg
Figure 3 Small intestine
Figure 3 Small intestine
(Enterocytes - Microvilli Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_5_2.jpg
Figure 4 Kidney
Figure 4 Kidney
(Proximal tubules (microvilli) Staining: High Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/43772/99239_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Group enriched (HEL, Hep G2, HMC-1)
Figure 5 RNA cell line category: Group enriched (HEL, Hep G2, HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000154269-ENPP3

Specifications

  • Antibody Overview
  • Fully Human Anti-ENPP3 IgG 2 k
  • Antibody Isotype
  • IgG 2 k
  • Linker
  • mc (maleimidocaproyl)
  • Linker Class/Description
  • Class: Noncleavable linker
    Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
  • Drug
  • MMAF (monomethyl auristatin F)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • The protein encoded by this gene belongs to a series of ectoenzymes that are involved in hydrolysis of extracellular nucleotides. These ectoenzymes possess ATPase and ATP pyrophosphatase activities and are type II transmembrane proteins. Expression of the related rat mRNA has been found in a subset of immature glial cells and in the alimentary tract. The corresponding rat protein has been detected in the pancreas, small intestine, colon, and liver. The human mRNA is expressed in glioma cells, prostate, and uterus. Expression of the human protein has been detected in uterus, basophils, and mast cells. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • ENPP3; ectonucleotide pyrophosphatase/phosphodiesterase 3; B10; NPP3; PDNP3; CD203c; PD-IBETA; ectonucleotide pyrophosphatase/phosphodiesterase family member 3; gp130RB13-6; phosphodiesterase-I beta; phosphodiesterase I/nucleotide pyrophosphatase 3; dJ914N13.3 (phosphodiesterase I/nucleotide pyrophosphatase 3); dJ1005H11.3 (phosphodiesterase I/nucleotide pyrophosphatase 3);

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

See other products for "ENPP3"

Recombinant Antibody

CAT Product Name Application Type
MOB-2302z Mouse Anti-ENPP3 Recombinant Antibody (clone 5C1) WB, ELISA, IP Mouse IgG2a, κ
MOB-0665CT Recombinant Mouse anti-Human ENPP3 Monoclonal antibody (OQ5E7) FC, ICC/IF
VS4-WK160 Human Anti-ENPP3 Recombinant Antibody (clone 3B2) ELISA, FC Human IgG1
VS-0723-WK17 Human Anti-ENPP3 Recombinant Antibody (clone Xencor) FC Human IgG1

Customer Reviews and Q&As

Submit a review or a question
There are currently no Customer reviews or questions for ADC-021LZY. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.

For Research Use Only. Not For Clinical Use.

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Send Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare