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Anti-LIV-1-vc-MMAE ADC (CAT#: ADC-046LZY)

This ADC product is composed of an anti-LIV-1 antibody conjugated via vc linker to MMAE (anti-LIV-1-vc-MMAE). It is in Phase I clinical trials and has demonstrated a response in Metastatic breast cancer treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.


Specific Inquiry
  • Gene Expression
  • Datasheet
  • MSDS
  • COA
Normal Tissue
Figure 1 IHC staining of human uterus, post-menopause
Figure 1 IHC staining of human uterus, post-menopause
(Immunohistochemical staining of human uterus, post-menopause shows strong cytoplasmic positivity in glandular cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_B_7_5.jpg
Figure 3 Colon
Figure 3 Colon
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_A_7_3.jpg
Figure 4 Liver
Figure 4 Liver
(Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_A_9_4.jpg
Figure 5 Kidney
Figure 5 Kidney
(Cells in glomeruli Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_A_9_5.jpg
Figure 6 Testis
Figure 6 Testis
(Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_A_4_6.jpg
Figure 7 Prostate
Figure 7 Prostate
(Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/42377/90512_A_1_5.jpg
RNA Expression
Figure 8 RNA cell line category: Low cell line specificity
Figure 8 RNA cell line category: Low cell line specificity
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141424-SLC39A6

Specifications

  • Antibody Overview
  • Humanized Anti-LIV-1 IgG1
  • Antibody Isotype
  • IgG1
  • Linker
  • VC (valine-citrulline)
  • Linker Class/Description
  • Class: peptide linker
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • MMAE (monomethyl auristatin E)
  • Drug Class/Description
  • Class: Auristatin
    Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.

Target

  • Introduction
  • Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003 [PubMed 12659941]).[supplied by OMIM, Mar 2008]
  • Alternative Names
  • SLC39A6; solute carrier family 39 (zinc transporter), member 6; LIV-1; zinc transporter ZIP6; ZIP-6; zrt-and Irt-like protein 6; estrogen-regulated protein LIV-1; LIV-1 protein, estrogen regulated; solute carrier family 39 member 6; solute carrier family 39 (metal ion transporter), member 6;

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Recombinant Antibody

CAT Product Name Application Type
MOB-143CQ Human Anti-Human slc39a6 Antibody Neut, ELISA, ICC Human IgG
MOB-382CQ Recombinant Mouse Anti-SLC39A6 Antibody (1.7A4) ELISA, WB Mouse IgG
MOB-178YJL Human Anti-SLC39A6 Recombinant Antibody (clone CBS1032) IHC, ELISA, FuncS Human IgG1
VS4-CJ117 Recombinant Human Anti-SLC39A6 Antibody (clone 13F1) ELISA Human IgG1

scFv Fragment Antibody

CAT Product Name Application Type
MOB-382CQ-S(P) Recombinant Mouse Anti-SLC39A6 Antibody scFv Fragment (1.7A4) ELISA, WB Mouse scFv
MOB-178YJL-S(P) Human Anti-SLC39A6 Recombinant Antibody (clone CBS1032); scFv Fragment IHC, ELISA, FuncS Human scFv

Fab Fragment Antibody

CAT Product Name Application Type
MOB-382CQ-F(E) Recombinant Mouse Anti-SLC39A6 Antibody Fab Fragment (1.7A4) ELISA, WB Mouse Fab
MOB-178YJL-F(E) Human Anti-SLC39A6 Recombinant Antibody (clone CBS1032); Fab Fragment IHC, ELISA, FuncS Human Fab

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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