Recombinant Anti-CDK4 Soluble TCR (UNC-CDK4-1) (ZIP-Fos/ZIP-Jun) (CAT#: VS-0622-YF885)
TCR (UNC-CDK4-1) recognizes CDK4 peptide (ALTPVVVTL) in the context of HLA-A*02:01. Soluble TCR expressed with ZIP-Fos/ZIP-Jun strategy (TRAV-TRAC partial-ZIP-Fos, TRBV-TRBC partial-ZIP-Jun) was validated to be able to bind pMHC in published references. The same expression strategy (ZIP-Fos/ZIP-Jun) is used to express this recombinant soluble TCR (UNC-CDK4-1). Please note that the activity is not guaranteed.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line MCF7
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
(Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, nucleoli, nuclear membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6024/1704_B1_1_cr5811e29350250_selected.jpg
Figure 2 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
(Immunohistochemical staining of human ovary shows strong nuclear positivity in ovarian stroma cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_4_7_selected.jpg
Figure 3 IHC staining of human endometrium
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
(Immunohistochemical staining of human endometrium shows moderate nuclear positivity in cells in endometrial stroma.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/69405/163411_B_5_3_selected.jpg
Figure 4 Colon
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
(Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Low Intensity: Moderate Quantity: <25% Enterocytes - Goblet cells Staining: Low Intensity: Moderate Quantity: <25% Mucosal lymphoid cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_7_3.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
(Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_5_6.jpg
Figure 6 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/13116/163415_A_9_8.jpg
Figure 7 RNA cell line category: Group enriched (HBEC3-KT, LHCN-M2, RH-30)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000135446-CDK4
Specifications
- Target
- CDK4
- Species Reactivity
- Human
- Epitope
- ALTPVVVTL
- MHC
- HLA-A*02:01
- Clone
- UNC-CDK4-1
- Type
- Soluble TCR (ZIP-Fos/ZIP-Jun)
- Related Disease
- Acute myeloid leukemia (AML)
- TCR Expression Strategy
- ZIP-Fos/ZIP-Jun strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on ZIP-Fox/ZIP-Jun. The soluble TCR contains variable regions and partial constant regions.
Target
Related Resources
Bladder Cancer
AGE-RAGE Signaling Pathway in Diabetic Complications
p53 Signaling Pathway
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone UNC-CDK4-1"
See other products for "CDK4"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2055z | Mouse Anti-CDK4 Recombinant Antibody (clone 23A2) | WB, ICC, IF, IHC | Mouse IgG |
| MRO-0339-CN | Mouse Anti-CDK4 Recombinant Antibody (clone 5-C3-G3) | WB, IF, IHC | Mouse IgG2c |
| MRO-0340-CN | Rabbit Anti-CDK4 Recombinant Antibody (clone CBACN-138) | WB, IF, IHC, FC | Rabbit IgG |
| MRO-0341-CN | Rabbit Anti-CDK4 Recombinant Antibody (clone CBACN-139) | WB, IF, IP | Rabbit IgG |
| ZG-0404F | Mouse Anti-Cdk4 Recombinant Antibody (ZG-0404F) | WB | Mouse IgG |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0113MZ | Chicken Anti-CDK4 Polyclonal IgY | WB | Chicken antibody |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0630 | Hi-Affi™ Rabbit Anti-CDK4 Recombinant Antibody (clone DS630AB) | ICC, IF, WB | Rabbit IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0622-YF885. Click the button above to contact us or submit your feedback about this product.
View the frequently asked questions answered by Creative Biolabs Support.
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.