B*07:02/EBV EBNA6 (QPRAPIRPI) MHC Monomer (CAT#: MHC-YF171)
This product is a MHC monomer of biotinylated peptide/MHC complex composed EBNA6-derived peptide of QPRAPIRPI sequence and B*07:02 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specific Inquiry
Specifications
- Allele
- B*07:02
- Class
- Class I
- MHC Species
- Human
- Antigen
- EBNA6
- Antigen Species
- EBV
- Peptide
- QPRAPIRPI
- Conjugate
- Biotin
- Application
- MHC Multimer
Target
- Antigen Introduction
- Plays an essential role for the activation and immortalization of human B-cells. Represses transcription of viral promoters TP1 and Cp through interaction with host RBPJ, and inhibits EBNA2-mediated activation of these promoters. Since Cp is the promoter for all EBNA mRNAs, EBNA6 probably contributes to a negative autoregulatory control loop. Alternatively, EBNA6 also regulates the transcription of the EBV oncogene LMP1 in a cell cycle-dependent manner. Modulates the activity of several host proteins involved in cell cycle regulation including host cyclin A, MYC, RB, p21 and p27 mainly through binding to the host SCF(SKP2) complex. Inhibits the promoter of host H2AX and targets H2AX to proteasomal degradation in order to promote latency and cell proliferation.
- Alternative Names
- Epstein-Barr nuclear antigen 6; EBNA-6; EBV nuclear antigen 6; Epstein-Barr nuclear antigen 3C;Epstein-Barr nuclear antigen 4B
- Gene ID
- 17494242
- UniProt ID
- P03204
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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