dAbs scaffold protein anti-human Insulin-like growth factor (IGF) (CAT#: SDS-L075)
The dAbs that bound insulin-like growth factor (IGF) was isolated from the library using Phage display techonology. After affinity maturation, dAbs variants were identified having affinities for insulin-like growth factor (IGF) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human colon
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Figure 3 Rectum
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
Specifications
- Scaffold Name
- dAbs
- Origin
- dAbs (human VH or VL single domain)
- Core Structure
- β-Sheet sandwich
- Variable Regions
- CDR 1, 2, 3
- Target
- Insulin-like growth factor (IGF)
- Species Reactivity
- human
- Expression Host
- BL21 (DE3) cells
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- dAbs (human VH or VL single domain); dAbs; MGF; IGFI; IGF-I
- Gene ID
- 3479
- UniProt ID
- P05019
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "IGF1"
Human Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-385CL | Anti-Human IGF1 Recombinant Antibody (BI 836845) | WB, FuncS | Antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1072CQ | Mouse Anti-IGF1 Recombinant Antibody (clone M23) | Neut, FC, ICC, IF | Mouse IgG1, κ |
| NEUT-1073CQ | Mouse Anti-IGF1 Recombinant Antibody (clone SPM406) | WB, Neut, FC, ICC, IF, IHC-P, IP | Mouse IgG1, κ |
| NEUT-1074CQ | Hamster Anti-Igf1 Recombinant Antibody (clone CBL534) | WB, ELISA, Neut | Hamster IgG |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1754 | Rabbit Anti-IGF1 Recombinant Antibody (clone DS1754AB) | WB | Rabbit IgG |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC | Mouse Anti-IGF1 Recombinant Antibody (HPAB-0038-YC) | ELISA | Mouse IgG |
| HPAB-0039-YC | Human Anti-IGF1 Recombinant Antibody (HPAB-0039-YC) | ELISA, Stim, Neut | Human IgG1 |
| HPAB-0160-YJ | Human Anti-IGF1 Recombinant Antibody (HPAB-0160-YJ) | ELISA, Neut, FuncS | Human IgG1 |
| HPAB-0161-YJ | Human Anti-IGF1 Recombinant Antibody (HPAB-0161-YJ) | ELISA, Neut, FuncS | Human IgG1 |
| HPAB-0556-YJ | Mouse Anti-IGF1 Recombinant Antibody (clone CBI65YJ) | ELISA | Mouse IgG |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC-S(P) | Mouse Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038-YC-S(P)) | ELISA | Mouse scFv |
| HPAB-0039-YC-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0039-YC-S(P)) | ELISA, Stim, Neut | Human scFv |
| HPAB-0038LY-S(P) | Human Anti-IGF1 Recombinant Antibody; scFv Fragment (HPAB-0038LY-S(P)) | WB | Human scfv |
| HPAB-646-FY-S(P) | Mouse Anti-IGF1 Recombinant Antibody (clone MuEM164); scFv Fragment | Inhib, FC | Mouse scFv |
| HPAB-647-FY-S(P) | Human Anti-IGF1 Recombinant Antibody (clone huEM164 V1.0); scFv Fragment | Inhib, FC | Human scFv |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0038-YC-F(E) | Mouse Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038-YC-F(E)) | ELISA | Mouse Fab |
| HPAB-0039-YC-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0039-YC-F(E)) | ELISA, Stim, Neut | Human Fab |
| HPAB-0770-CN-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0770-CN-F(E)) | WB, FC | Human Fab |
| HPAB-0771-CN-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0771-CN-F(E)) | WB, FC | Human Fab |
| HPAB-0038LY-F(E) | Human Anti-IGF1 Recombinant Antibody; Fab Fragment (HPAB-0038LY-F(E)) | WB | Human Fab |
MHC Tetramer for Cancer
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0897 | PE-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0898 | APC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0899 | FITC-H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC | |
| MHC-CN0900 | H-2Db/Human IGF1 (SHLVEALYL) MHC Tetramer | FCM, IHC |
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