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DRB1*04:01/Human cit CILP (ATIKAEFV[cit]AETPYM) MHC Monomer (CAT#: MHC-YF040)

This product is a MHC monomer of biotinylated peptide/MHC complex composed cit CILP-derived peptide of ATIKAEFV[cit]AETPYM sequence covering 297–311 and DRB1*04:01 molecule. The pMHC monomer recognizes human CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.


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Normal Tissue
Figure 1 IHC staining of human ovary
Figure 1 IHC staining of human ovary
(Immunohistochemical staining of human ovary shows strong cytoplasmic positivity in follicle cells.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/ihc_selected.jpg
Figure 2 Cerebral cortex
Figure 2 Cerebral cortex
(Neuronal cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_B_8_5.jpg
Figure 3 Liver
Figure 3 Liver
(Cholangiocytes Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Hepatocytes Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_7_4.jpg
Figure 4 Kidney
Figure 4 Kidney
(Cells in glomeruli Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_9_5.jpg
Figure 5 Testis
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3195/9797_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, EFO-21, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000138615-CILP

Specifications

  • Allele
  • DRB1*04:01
  • Class
  • Class II
  • Antigen
  • cit CILP
  • Antigen Species
  • Human
  • Peptide
  • ATIKAEFV[cit]AETPYM
  • Range
  • 297–311
  • Conjugate
  • Biotin
  • Application
  • MHC Multimer

Target

  • Antigen Introduction
  • Major alterations in the composition of the cartilage extracellular matrix occur in joint disease, such as osteoarthrosis. This gene encodes the cartilage intermediate layer protein (CILP), which increases in early osteoarthrosis cartilage. The encoded protein was thought to encode a protein precursor for two different proteins; an N-terminal CILP and a C-terminal homolog of NTPPHase, however, later studies identified no nucleotide pyrophosphatase phosphodiesterase (NPP) activity. The full-length and the N-terminal domain of this protein was shown to function as an IGF-1 antagonist. An allelic variant of this gene has been associated with lumbar disc disease.
  • Alternative Names
  • CILP-1; HsT18872

Downloads

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Recombinant Antibody

CAT Product Name Application Type
MOB-1896z Mouse Anti-CILP Recombinant Antibody (clone 29D11) WB, ELISA, IF, IP Mouse IgG1, κ

MHC Tetramer for Other Applications

CAT Product Name Application Type
MHC-YF041 DRB1*04:01/Human cit CILP (GKLYGI[cit]DV[cit]STRDR) MHC Monomer MHC Multimer

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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

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