Anti-Cripto protein (huB3F6)-Disulfide-linker-DM4 ADC (CAT#: ADC-094LCT)
This ADC product is composed of an anti-Cripto protein antibody (clone huB3F6) conjuagated via a Disulfide-linker to DM4 (huB3F6-Disulfide-linker-DM4). It has demonstrated a response in Solid tumors treatment by a MOA (Mechanism of Action) of Depolymerize Microtubules.
Specific Inquiry
Subcellular Location
RNA Expression
Figure 1 IF staining of human cell line U-2 OS
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51928/1650_B2_43_cr57ea9a8572196_selected.jpg
(Immunofluorescent staining of human cell line U-2 OS shows localization to vesicles.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/51928/1650_B2_43_cr57ea9a8572196_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (HEL, NTERA-2, SuSa)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000241186-TDGF1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000241186-TDGF1
Specifications
- Antibody Overview
- huB3F6 (Humanized IgGl / kappa monoclonal Antibody)
- Clone
- huB3F6
- Linker
- Disulfide-linker
- Linker Class/Description
- Disulfide Linkers are extensively exploited as a chemically labile linkage. Since the release of disulfide-linked drugs requires a cytoplasmic thiol cofactor, such as glutathione (GSH). Disulfides maintain stable at physiological pH and only when ADCs are internalized inside cells, the cytosol provides reducing environment including intracellular enzyme protein disulfide isomerase, or similar enzymes, drugs can be released.
- Drug
- DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
- Drug Class/Description
- Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
- Introduction
- This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- Alternative Names
- TDGF1; teratocarcinoma-derived growth factor 1; CR; CRGF; CRIPTO; cripto-1 growth factor; epidermal growth factor-like cripto protein CR1;
- Gene ID
- 6997
- UniProt ID
- F5H1T8
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2436z | Mouse Anti-TDGF1 Recombinant Antibody (MOB-2436z) | ELISA, WB, IHC, IP, IF, FC | Mouse IgG |
| HPAB-1431-FY | Human Anti-TDGF1 Recombinant Antibody (HPAB-1431-FY) | Inhib | Humanized IgG |
| ZG-0437F | Mouse Anti-TDGF1 Recombinant Antibody (ZG-0437F) | WB, ELISA | Mouse IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2436z-F(E) | Recombinant Anti-Human TDGF1 Antibody Fab Fragment | RIA, WB, FuncS | Fab |
| HPAB-1431-FY-S(P) | Human Anti-TDGF1 Recombinant Antibody; scFv Fragment (HPAB-1431-FY-S(P)) | Inhib | Humanized scFv |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2436z-S(P) | Recombinant Anti-Human TDGF1 Antibody scFv Fragment | ELISA, IF, FuncS | scFv |
| HPAB-1431-FY-F(E) | Human Anti-TDGF1 Recombinant Antibody; Fab Fragment (HPAB-1431-FY-F(E)) | Inhib | Humanized Fab |
Chicken IgY Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0579MZ | Chicken Anti-TDGF1 Polyclonal IgY | WB | Chicken antibody |
Neutralizing Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1989CQ | Mouse Anti-TDGF1 Recombinant Antibody (clone 6M17) | Neut, WB | Mouse IgG1 |
| NEUT-1990CQ | Mouse Anti-TDGF1 Recombinant Antibody (clone CBL032) | Neut, WB | Mouse IgG1 |
Blocking Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1991CQ | Mouse Anti-TDGF1 Recombinant Antibody (clone CBL310) | Block, ICC, ELISA | Mouse IgG1 |
| NEUT-1992CQ | Mouse Anti-Tdgf1 Recombinant Antibody (clone CBL357) | Block, CyTOF, FC, ICC | Mouse IgG2b |
Rabbit Monoclonal Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3526 | Rabbit Anti-TDGF1 Recombinant Antibody (clone DS3526AB) | ICC, IP, WB | Rabbit IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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