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ARHGAP31
This gene encodes a GTPase-activating protein (GAP). A variety of cellular processes are regulated by Rho GTPases which cycle between an inactive form bound to GDP and an active form bound to GTP. This cycling between inactive and active forms is regulated by guanine nucleotide exchange factors and GAPs. The encoded protein is a GAP shown to regulate two GTPases involved in protein trafficking and cell growth. [provided by RefSeq, Jul 2008]
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, Microglial cells, Astrocytes, Langerhans cells, Adipocytes, Endothelial cells)
Immune cell specificity
Immune cell enhanced (myeloid DC)
Cell line specificity
Cell line enhanced (HUVEC TERT2, TIME)
Interaction
Interacts with ITSN1, which inhibits GAP activity. Interacts with PARVA (By similarity). Interacts with GTP-loaded RHOU.
Molecular function
GTPase activation
More Types Infomation
- PE-B*07:02/Human ARHGAP31 (RPAKSMDSL) MHC Tetramer (MHC-LC4482)
-
- Class: Class I
- Antigen: ARHGAP31
- Antigen Species: Human
- Peptide: RPAKSMDSL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.