CD markers, G-protein coupled receptors, Human disease related genes
Membrane
Cell type enhanced (Kupffer cells, dendritic cells, monocytes, Plasma cells, Macrophages)
Immune cell enhanced (basophil)
Cell line enhanced (Karpas-707, THP-1, U-266/70, U-266/84)
Interacts with ARRB1 (PubMed:9501202). Interacts (via extracellular N-terminal region) with beta-defensin DEFB106A/DEFB106B; this interaction may preferentially require specific tyrosine sulfation on CCR2 (PubMed:23938203). Interacts with NUP85; the interaction is required for CCR2 clusters formation on the cell membrane and CCR2 signaling (PubMed:15995708, 25283965). (Microbial infection) Binds to HIV-1 Tat.
G-protein coupled receptor, Receptor, Transducer
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For Research Use Only. Not For Clinical Use.