Lipopolysaccharide (LPS) is a component of the cell wall of Escherichia coli, a Gram-negative bacterium, and lipopolysaccharide is toxic to the host. Lipopolysaccharide is released only when the bacteria die or dissolve the cells by artificial means, so it is called endotoxin. Lipopolysaccharide consists of three parts: lipid A, core polysaccharide, O-antigen. Lipid A is a glycolipid that constitutes endotoxin activity and is covalently linked to the heteropolysaccharide chain. There are two parts: the core polysaccharide, which is constant in the relevant strain; the specific chain (O-specific chain) is highly variable. Lipopolysaccharide of Escherichia coli is a commonly used B cell mitogenic factor, a polyclonal activating factor, in laboratory immunology.