Intracellular, Secreted (different isoforms)
Cell type enriched (Ionocytes)
Not detected in immune cells
Cell line enhanced (BJ hTERT+, PC-3, RT4)
Interacts with SMAD3. Binds IL18R1, but not to IL1R1, with lower affinity than IL18, and does not seem to act as a receptor antagonist for IL18. Interacts with cargo receptor TMED10; the interaction mediates the translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and thereby secretion (PubMed:32272059).
Cytokine
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For Research Use Only. Not For Clinical Use.