Cancer-related genes, FDA approved drug targets, Plasma proteins
Intracellular, Membrane (different isoforms)
Cell type enhanced (NK-cells, Plasma cells, T-cells, dendritic cells, B-cells)
Low immune cell specificity
Group enriched (Karpas-707, RPMI-8226)
Heterodimer of an alpha and a beta subunit. Beta-7 associates with either alpha-4 or alpha-E. Integrin alpha-4/beta-7 interacts with MADCAM1, VCAM1, fibronectin, and may also interact with HIV-1 gp120. Interacts with FLNA (via filamin repeats 4, 9, 12, 17, 19, 21, and 23) (PubMed:19828450).
Host cell receptor for virus entry, Integrin, Receptor
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For Research Use Only. Not For Clinical Use.