Cancer-related genes, Plasma proteins
Intracellular
Cell type enriched (Late spermatids)
Immune cell enhanced (T-reg)
Low cell line specificity
Interacts with CENPH. Interacts with MTUS2/TIP150; the interaction is direct. Interacts with MAPRE1; the interaction is direct, regulated by phosphorylation and is probably required for targeting to growing microtubule plus ends. Interacts with KIF18B at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. Phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding.
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For Research Use Only. Not For Clinical Use.