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KLK3

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Protein class

Cancer-related genes, Enzymes, FDA approved drug targets, Plasma proteins

Predicted location

Secreted

Single cell type specificity

Cell type enriched (Prostatic glandular cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BEWO, NB-4, RPMI-8226, SH-SY5Y, U-2197)

Interaction

Forms a heterodimer with SERPINA5.

Molecular function

Hydrolase, Protease, Serine protease

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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