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LAMTOR5
This gene encodes a protein that specifically complexes with the C-terminus of hepatitis B virus X protein (HBx). The function of this protein is to negatively regulate HBx activity and thus to alter the replication life cycle of the virus. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Homodimer (PubMed:21059355). Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer (PubMed:22980980). The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability (PubMed:22980980). The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (PubMed:25561175, 25567906). Component of the lysosomal folliculin complex (LFC), composed of FLCN, FNIP1 (or FNIP2), RRAGA/RagA or RRAGB/RagB GDP-bound, RRAGC/RagC or RRAGD/RagD GTP-bound, and Ragulator (PubMed:31704029, 31672913). Interacts with phosphorylated BIRC5; the resulting complex binds pro-caspase-9, as well as active caspase-9, but much less efficiently (PubMed:12773388). Interacts with SUPV3L1 (PubMed:16176273). (Microbial infection) Interacts with hepatitis B virus (HBV) oncoprotein HBX C-terminus.
More Types Infomation
- PE-B*40:01/Human LAMTOR5 (EHAGVISVL) MHC Tetramer (MHC-LC4380)
-
- Class: Class I
- Antigen: LAMTOR5
- Antigen Species: Human
- Peptide: EHAGVISVL
- Conjugate: PE
- PE-A*69:01/Human LAMTOR5 (EHAGVISVL) MHC Tetramer (MHC-LC4379)
-
- Class: Class I
- Antigen: LAMTOR5
- Antigen Species: Human
- Peptide: EHAGVISVL
- Conjugate: PE
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For Research Use Only. Not For Clinical Use.