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LMNA
Pre-lamin A/C or lamin A/C is a protein that in humans is encoded by the LMNA gene.
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Langerhans cells)
Immune cell specificity
Immune cell enhanced (myeloid DC, T-reg)
Cell line specificity
Low cell line specificity
Interaction
Homodimer of lamin A and lamin C. Interacts with lamin-associated polypeptides IA, IB and TMPO-alpha, RB1 and with emerin. Interacts with SREBF1, SREBF2, SUN2 and TMEM43. Interacts with TMEM201 (By similarity). Proteolytically processed isoform A interacts with NARF. Interacts with SUN1. Prelamin-A/C interacts with EMD. Interacts with MLIP. Interacts with DMPK; may regulate nuclear envelope stability. Interacts with SUV39H1; the interaction increases stability of SUV39H1. Interacts with SYNE2. Interacts with ITSN1 isoform 2 (PubMed:29599122). Interacts with IFFO1; enables the formation of an interior nucleoskeleton that is recruited to DNA double-strand breaks (PubMed:31548606). [Isoform C]: Interacts (via C-terminus) with LEMD2 (via N-terminus) (in vitro).
More Types Infomation
- PE-A*02:01/Human LMNA (RLAVYIDRV) MHC Tetramer (MHC-LC1922)
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- Class: Class I
- Antigen: LMNA
- Antigen Species: Human
- Peptide: RLAVYIDRV
- Conjugate: PE
- PE-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer (MHC-CN0130)
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- Class: Class I
- Antigen: Lamin
- Antigen Species: Human
- Peptide: KAGQVVTIW
- Conjugate: PE
- APC-B*58:01/Human Lamin (KAGQVVTIW) MHC Tetramer (MHC-CN0129)
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- Class: Class I
- Antigen: Lamin
- Antigen Species: Human
- Peptide: KAGQVVTIW
- Conjugate: APC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG3
- Application: ICC, IF, IHC
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: FC, ICC/IF, IHC-Fr, IHC-P, IP, WB
-
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: FC, ICC/IF, IHC-P, IP, WB
-
- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF
-
- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF, IP
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- Derivation: Mouse
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG2a
- Application: WB
- Mouse Anti-LMNA Recombinant Antibody (clone 4E7) (VS3-XY1013)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB, IHC
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ELISA, IHC, IF, FC, IP
- Chicken Anti-LMNA Polyclonal IgY (BRD-0327MZ)
-
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ICC
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB
-
- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, IHC, ELISA
- Chicken Anti-Lamin A/C Polyclonal IgY (BRD-1186MZ)
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- Species Reactivity: Human, Bovine, Porcine, Mouse, Rat
- Type: Chicken antibody
- Application: N/A
- Mouse Anti-LMNA Recombinant Antibody (VS3-CJ299) (VS3-CJ299)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG1, κ
- Application: WB
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ICC, IF, IP
-
- Species Reactivity: Cow, Dog, Human, Mouse, Rat
- Type: Mouse IgG3
- Application: FC, ICC, IHC-Fr
-
- Species Reactivity: Cow, Dog, Hamster, Human, Mouse, Rat, Sheep
- Type: Mouse IgG1
- Application: FC, ICC, IHC-Fr
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For Research Use Only. Not For Clinical Use.