NC-GC

GCK127 and GCK152 have their O-glycosidic linkages replaced with an E-alkene linker between the sugar and lipid moieties, reminiscent of C-glycoside (-C-GalCer), whereas GCK152 also has a truncated fatty acid with a terminal phenyl group. Naphthylcarba-GalCer (NC-GC) has an aromatic 6-OH galactose modification, similar to the previously crystallized naphthylurea (NU)-GC. However, unlike NU-GC where the naphthyl is linked via a urea group, NC-GC has a carbamate linker, which provides more flexibility to the naphthyl moiety.