PMCA ATPase

Plasma membrane Ca2 +-ATPase (plasma be Ca2 +-ATPase, PMCA) is one of the most important proteins regulating intracellular Ca2 + concentration. In 1966, for the first time Schatzmann the Ca2 + dependent ATPase red blood cells and the associated Ca2 + transport out of the physiological activities of the red blood cells, truly confirmed PMCA and began the study of its. PMCA generally exists in all kinds of the plasma membrane of eukaryotic cells, but its content is very low. In 1979, Niggli such as use of calmodulin affinity chromatography to largerer PMCA purification, studies of PMCA is becoming more and more widely And deep. PMCA exerts its effect well after the signal stimulation of Ca2 + mop-up, and maintain intracellular Ca2 + concentration in resting condition. Recently, a large number of studies have shown that it is directly involved in regulation of signal transduction process in some organizations, such as heart this way effect the Ca2 + transport accounts for more important position. In addition, the PMCA contact there exists a certain cell apoptosis.