Intracellular, Membrane (different isoforms)
Cell type enhanced (Proximal tubular cells, Hepatocytes)
Low immune cell specificity
Cell line enhanced (CAPAN-2, MCF7)
Interacts with IL1R1, IRAK1, TLR4, TLR5, TLR9 and TRAF6. Upon IL-1 stimulation found in a complex at least composed of IL1R1, SIGIRR, MYD88, IRAK1 and TRAF6. Upon stimulation with LPC found in a complex at least composed of TLR4, SIG1IR, MYD88, IRAK1 and TRAF6. Interacts with PALM3.
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For Research Use Only. Not For Clinical Use.