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TNFRSF11A
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptors can interact with various TRAF family proteins, through which this receptor induces the activation of NF-kappa B and MAPK8/JNK. This receptor and its ligand are important regulators of the interaction between T cells and dendritic cells. This receptor is also an essential mediator for osteoclast and lymph node development. Mutations at this locus have been associated with familial expansile osteolysis, autosomal recessive osteopetrosis, and Paget disease of bone. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2012]
Protein class
CD markers, Disease related genes, Human disease related genes
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Paneth cells, Undifferentiated cells, Distal enterocytes, Proximal enterocytes, Intestinal goblet cells)
Immune cell specificity
Immune cell enriched (NK-cell)
Cell line specificity
Cell line enriched (HDLM-2)
Interaction
Binds to the clefts between the subunits of the TNFSF11 ligand trimer to form a heterohexamer (By similarity). Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Interacts (via cytoplasmic domain) with GAB2.
Molecular function
Receptor
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
-
- Species Reactivity: Human
- Application: FC, IP, WB
- Mouse Anti-TNFRSF11A Recombinant Antibody (clone 9A725) (NEUT-2117CQ)
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG1, κ
- Application: FC, Neut
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For Research Use Only. Not For Clinical Use.