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TUBB4A
This gene encodes a member of the beta tubulin family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene cause hypomyelinating leukodystrophy-6 and autosomal dominant torsion dystonia-4. Alternate splicing results in multiple transcript variants encoding different isoforms. A pseudogene of this gene is found on chromosome X. [provided by RefSeq, Jan 2014]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Theca cells, Muller glia cells, Excitatory neurons)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (AN3-CA, HAP1, HEL, PC-3, REH, SH-SY5Y)
Interaction
Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.
More Types Infomation
-
- Class: Class I
- Antigen: Tubulin beta 4
- Antigen Species: Human
- Peptide: FLALIICNA
- Conjugate: Unlabeled, Biotin, R-PE, APC
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For Research Use Only. Not For Clinical Use.