Membrane, Secreted (different isoforms)
Cell type enhanced (Adipocytes, Basal respiratory cells, dendritic cells)
Immune cell enhanced (gdT-cell)
Cell line enhanced (SiHa, U-2197)
Interacts with KLRK1/NKG2D (PubMed:11777960). Does not bind to beta2-microglobulin (PubMed:12782710). (Microbial infection) In CMV-infected cells, interacts with the viral glycoprotein UL16; this interaction causes ULBP2 retention in the endoplasmic reticulum and cis-Golgi and prevents binding to and activation of KLRK1/NKG2D, providing CMV with an immune evasion mechanism.
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For Research Use Only. Not For Clinical Use.