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Ubqln1
This gene encodes an ubiquitin-like protein (ubiquilin) that shares a high degree of similarity with related products in yeast, rat and frog. Ubiquilins contain an N-terminal ubiquitin-like domain and a C-terminal ubiquitin-associated domain. They physically associate with both proteasomes and ubiquitin ligases, and thus are thought to functionally link the ubiquitination machinery to the proteasome to affect in vivo protein degradation. This ubiquilin has also been shown to modulate accumulation of presenilin proteins, and it is found in lesions associated with Alzheimer's and Parkinson's disease. Two transcript variants encoding different isoforms have been found for this gene.
Protein class
Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Monomer and homodimer (PubMed:16813565). Heterodimer with UBQLN2 (PubMed:16813565). Binds CD47, NBL1, GABRA1, GABRA2, GABRA3, GABRA6, GABRB1, GABRB2 and GABRB3 (By similarity). Binds UBE3A, BTRC, P4HB and MTOR. Interacts with the proteasome 19S subunit. Interacts (via ubiquitin-like domain) with TREX1; the interaction is direct and may control TREX1 subcellular location. Forms a complex with UBXN4 and VCP. Interacts (via UBA domain) with UBQLN4 (via ubiquitin-like domain). Found in a complex with UBQLN2 and MAP1LC3A/B/C. The monomeric form interacts with PSEN2. The monomeric form interacts with PSEN1 (PubMed:11076969, PubMed:21143716). Interacts with ORAI1. Interacts (via UBA domain) with TICAM1. Interacts with EPS15. Interacts (via UBA domain) with UBA52 and (via ubiquitin-like domain) with PSMD3 and PSMD4. Interacts with HERPUD1. Interacts with MAP1LC3A/B/C in the presence of UBQLN4. Interacts (via ubiquitin-like domain) with EPS15 (via UIM domains) and both the ubiquitinated and non-ubiquitinated forms can interact with EPS15. Interacts (via ubiquitin-like domain) with EPS15L1, HGS (via UIM domain) and STAM2 (via UIM domain). Interacts with BCL2L10/BCL-B; in the cytoplasm (PubMed:22233804). [Isoform 1]: Monomeric form interacts with PSEN1. [Isoform 3]: Monomeric form interacts with PSEN1.
More Types Infomation
- BV421-RT1/Rat Ubqln1 (NPRAMQALL) MHC Tetramer (MHC-LC1186)
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- Class: Class I
- Antigen: Ubqln1
- Antigen Species: Rat
- Peptide: NPRAMQALL
- Conjugate: BV421
- PE-RT1/Rat Ubqln1 (NPRAMQALL) MHC Tetramer (MHC-LC1184)
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- Class: Class I
- Antigen: Ubqln1
- Antigen Species: Rat
- Peptide: NPRAMQALL
- Conjugate: PE
- APC-RT1/Rat Ubqln1 (NPRAMQALL) MHC Tetramer (MHC-LC1185)
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- Class: Class I
- Antigen: Ubqln1
- Antigen Species: Rat
- Peptide: NPRAMQALL
- Conjugate: APC
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For Research Use Only. Not For Clinical Use.