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ANLN
This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocytes, Early spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HBF TERT88)
Interaction
Interacts with F-actin (PubMed:10931866). Interacts with CD2AP (PubMed:15800069). May interact with RHOA (PubMed:16357138). Interacts with FZR1/CDH1 during mitotic exit (PubMed:16040610).
Molecular function
Actin-binding
More Types Infomation
- PE-A*69:01/Human ANLN (GSEDRDLLY) MHC Tetramer (MHC-LC4469)
-
- Class: Class I
- Antigen: ANLN
- Antigen Species: Human
- Peptide: GSEDRDLLY
- Conjugate: PE
- PE-A*01:01/Human ANLN (GSEDRDLLY) MHC Tetramer (MHC-LC4468)
-
- Class: Class I
- Antigen: ANLN
- Antigen Species: Human
- Peptide: GSEDRDLLY
- Conjugate: PE
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.