asTF

Alternative splicing of TF pre-mRNA yields alternatively spliced TF (asTF). asTF lacks the transmembrane domain and can thus be secreted. In humans and mice, asTF contains a novel C-terminus with poor homology to any known proteins. High expression of asTF expression in tumor cell lines suggests a role in tumor progression. Subcutaneous growth of pancreatic cancer cells overexpressing asTF, results in larger and more vascularized tumors. We recently discovered that asTF induces angiogenesis, independent of PAR2 activation, by acting as an integrin ligand. Thus, flTF and asTF facilitate cellular signaling via distinct mechanisms critical to tumor cell behavior.