Disease related genes, Human disease related genes
Intracellular
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes, Oligodendrocyte precursor cells)
Low immune cell specificity
Cell line enhanced (U-266/70)
Homooligomer (PubMed:9097953). Interacts with CIC (By similarity). Interacts with ANP32A, PQBP1, UBQLN4, ATXN1L and USP7 (PubMed:9353121, PubMed:11001934, PubMed:12062018, PubMed:12093161, PubMed:16121196). Directly interacts with RBPJ; this interaction is disrupted in the presence of Notch intracellular domain. Competes with ATXN1L for RBPJ-binding (PubMed:21475249). Found in a complex with CIC and ATXN1L (By similarity).
DNA-binding, Repressor, RNA-binding
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For Research Use Only. Not For Clinical Use.