Popular Searches: Recombinant Antibody MHC Tetramer T cell Receptor Scaffold Protein
Loading...
Custom Services order now ship next day

BIRC3

Engineered Antibody
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified.
Protein class

Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Langerhans cells, monocytes, Proximal enterocytes, granulocytes)

Immune cell specificity

Immune cell enhanced (memory B-cell, naive B-cell)

Cell line specificity

Cell line enhanced (CAPAN-2, Daudi, EFO-21, HDLM-2, hTERT-HME1, U-266/70, U-266/84)

Interaction

Interacts with PRSS25; interaction inhibits apoptotic suppressor activity. The BIR motifs region interacts with TNF receptor associated factors 1 and 2 (TRAF1 and TRAF2) to form a heteromeric complex, which is then recruited to the tumor necrosis factor receptor 2 (TNFR2). Interaction with TRAF2 is required for ubiquitination of IKBKE, degradation of NFKBIA and activation of NF-kappa-B. Interacts with RIP1, RIP2, RIP3, RIP4 and USP19.

Molecular function

Transferase

More Types Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

For Research Use Only. Not For Clinical Use.

© 2024 Creative Biolabs.
  • 0
  • 0
Cart
    Inquiry

    Go to compare