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CACNA2D3
This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Protein class
FDA approved drug targets, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocyte precursor cells, Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (BJ hTERT+, HAP1, HeLa)
Interaction
Dimer formed of alpha-2-2 and delta-2 chains; disulfide-linked. Voltage-dependent calcium channels are multisubunit complexes, consisting of alpha-1 (CACNA1), alpha-2 (CACNA2D), beta (CACNB) and delta (CACNA2D) subunits in a 1:1:1:1 ratio (By similarity).
Molecular function
Calcium channel, Ion channel, Voltage-gated channel
More Types Infomation
- Recombinant Anti-Human CACNA2D3 Antibody (MOB-3817z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, WB, IP, FuncS
- Recombinant Anti-Human CACNA2D3 Antibody scFv Fragment (MOB-3817z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, WB, IP, FuncS
- Recombinant Anti-Human CACNA2D3 Antibody Fab Fragment (MOB-3817z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, IF, FuncS
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For Research Use Only. Not For Clinical Use.