Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Intracellular
Group enriched (Early spermatids, Melanocytes, Oligodendrocytes, Late spermatids)
Low immune cell specificity
Cell line enriched (SK-MEL-30)
Homodimer; via EF-hand domain 4 (PubMed:24846670). Interacts with TTN/titin (PubMed:14583192). Interacts with CMYA5; this interaction, which results in CMYA5 proteolysis, may protect CAPN3 from autolysis (PubMed:20634290). Interacts with SIMC1 (PubMed:23707407). Interacts with UTP25; the interaction is required for CAPN3 translocation to the nucleolus (PubMed:23357851, PubMed:27657329).
Hydrolase, Protease, Thiol protease
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For Research Use Only. Not For Clinical Use.