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CAV2

The protein encoded by this gene is a major component of the inner surface of caveolae, small invaginations of the plasma membrane, and is involved in essential cellular functions, including signal transduction, lipid metabolism, cellular growth control and apoptosis.
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Alveolar cells type 1, Basal keratinocytes, Pancreatic endocrine cells, Prostatic glandular cells)

Immune cell specificity

Immune cell enriched (basophil)

Cell line specificity

Cell line enhanced (CAPAN-2, HBEC3-KT, LHCN-M2)

Interaction

Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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