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CBLB
Protein class
Cancer-related genes, Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocyte precursor cells, dendritic cells, Inhibitory neurons, T-cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (U-138 MG)
Interaction
Interacts with SH3 domain-containing proteins LCK, CRK and SORBS1. Interacts with LCP2 and ZAP70. Interacts with CBL (PubMed:29237719). Interacts with SH3 domain-containing proteins VAV1, FYN, FGR, PLCG1, GRB2, CRKL, PIK3R1 and SH3KBP1/CIN85. Identified in heterotrimeric complexes with SH3KBP1/CIN85, CD2AP and ARHGEF7, where one CBLB peptide binds two copies of the other protein. Interacts with poly-ubiquitinated proteins. Dimerization is required for the binding of poly-ubiquitin, but not for the binding of mono-ubiquitin. Interacts with EGFR (phosphorylated). Interacts with IFT20 (PubMed:29237719).
Molecular function
Transferase
More Types Infomation
- Mouse Anti-CBLB Recombinant Antibody (clone 357D6b) (MOB-0345CT)
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: DB, WB
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For Research Use Only. Not For Clinical Use.