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CDC14A
The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Late spermatids, Early spermatids, Astrocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (K-562)
Interaction
Interacts with KIF20A, which is required to localize CDC14 to the midzone of the mitotic spindle.
Molecular function
Hydrolase, Protein phosphatase
More Types Infomation
-
- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, ICC, IP, WB
- Chicken Anti-CDC14 (ab3) Polyclonal IgY (BRD-0106MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
- Chicken Anti-CDC14 (ab2) Polyclonal IgY (BRD-0105MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
- Chicken Anti-CDC14 (ab1) Polyclonal IgY (BRD-0104MZ)
-
- Species Reactivity: Human
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.