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CITED1
This gene encodes a member of the CREB-binding protein/p300-interacting transactivator with Asp/Glu-rich C-terminal domain (CITED) family of proteins. The encoded protein, also known as melanocyte-specific gene 1, may function as a transcriptional coactivator and may play a role in pigmentation of melanocytes. Alternatively spliced transcript variants have been described.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Breast glandular cells, Late spermatids, Breast myoepithelial cells, Paneth cells, Granulosa cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (SK-MEL-30)
Interaction
Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.
Molecular function
Activator, Developmental protein
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, WB
- Recombinant Mouse Anti-Human CITED1 Antibody (MOB-2148MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA, IHC-P, WB
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For Research Use Only. Not For Clinical Use.