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DCHS1

This gene is a member of the cadherin superfamily whose members encode calcium-dependent cell-cell adhesion molecules. The encoded protein has a signal peptide, 27 cadherin repeat domains and a unique cytoplasmic region. This particular cadherin family member is expressed in fibroblasts but not in melanocytes or keratinocytes. The cell-cell adhesion of fibroblasts is thought to be necessary for wound healing. [provided by RefSeq, Jul 2008]
Protein class

Disease related genes, Human disease related genes, Plasma proteins

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Hepatic stellate cells, Adipocytes, Endothelial cells, Granulosa cells, Endometrial stromal cells, Fibroblasts)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AF22, HUVEC TERT2, REH, SH-SY5Y, TIME)

Interaction

Heterophilic interaction with FAT4; this interaction affects their respective protein levels.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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