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DEFA6
Protein class
Plasma proteins
Predicted location
Secreted
Single cell type specificity
Group enriched (Undifferentiated cells, Proximal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (BEWO, NB-4, RPMI-8226, SH-SY5Y, U-2197)
Interaction
Homodimer (PubMed:17088326, PubMed:27076903). Self-assembles into higher-order oligomers termed nanonets, fibril-like structures that entrap microbes (PubMed:22722251). Self-assembly into nanonets seems to protect against proteolytic digestion in duodenal fluid (PubMed:30808760). Interacts with Y.enterocolitica invasin and S.typhimurium fliC/flagellin; the interaction creates an anchoring site for progressive DEFA6 self-assembly into nanonets (PubMed:22722251).
Molecular function
Antibiotic, Antimicrobial, Defensin, Fungicide
More Types Infomation
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ELISA
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For Research Use Only. Not For Clinical Use.