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DIXDC1
The protein encoded by this gene is a positive regulator of the Wnt signaling pathway. The encoded protein is found associated with gamma tubulin at the centrosome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Horizontal cells, Cone photoreceptor cells)
Immune cell specificity
Immune cell enriched (eosinophil)
Cell line specificity
Cell line enhanced (hTERT-HME1, TIME)
Interaction
Isoform 1 but not isoform 2 binds filamentous actin. Interacts with the complex composed of DVL2 and Rac. Interacts with AXIN1; competes with MAP3K1. Interacts with MAP3K4 preventing MAP3K4 interaction with AXIN1. Directly interacts (via DIX domain) with DVL2 (via DIX domain). Interacts with gamma-tubulin.
Molecular function
Actin-binding, Developmental protein
More Types Infomation
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IP, IF, ELISA
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For Research Use Only. Not For Clinical Use.