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DNM1
This gene encodes a member of the dynamin subfamily of GTP-binding proteins. The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes. Actin and other cytoskeletal proteins act as binding partners for the encoded protein, which can also self-assemble leading to stimulation of GTPase activity. More than sixty highly conserved copies of the 3' region of this gene are found elsewhere in the genome, particularly on chromosomes Y and 15. Alternatively spliced transcript variants encoding different isoforms have been described.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Inhibitory neurons, Excitatory neurons, Bipolar cells, Cone photoreceptor cells, Rod photoreceptor cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A549, U-87 MG)
Interaction
Interacts with CAV1 and SH3GLB1. Binds SH3GL1, SH3GL2 and SH3GL3 (By similarity). Interacts with PHOCN. Interacts with PACSIN1, PACSIN2 and PACSIN3 (By similarity). Interacts with SNX9. Interacts with MYO1E (via SH3 domain). Interacts with SNX33 (via SH3 domain). Interacts with UNC119; leading to a decrease of DNM1 GTPase activity (By similarity). Interacts with DIAPH1 (PubMed:23325789). Interacts with AMPH, BIN1 AND SYNJ1 (By similarity).
Molecular function
Hydrolase, Motor protein
More Types Infomation
- Recombinant Anti-Human DNM1 Antibody scFv Fragment (MOB-3310z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, RIA, Biosensors, FuncS
- Recombinant Anti-Human DNM1 Antibody Fab Fragment (MOB-3310z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, IP, FuncS
-
- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IP, WB
-
- Species Reactivity: Human
- Application: WB, ICC, IP
- Mouse Anti-DNM1 Recombinant Antibody (MOB-3310z) (MOB-3310z)
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- Species Reactivity: Human, Mouse, Rat, Monkey
- Type: Mouse IgG2a
- Application: WB, IP
- Rabbit Anti-DNM1 Polyclonal Antibody (MRO-1827-CN) (MRO-1827-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, IF
-
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC, ELISA
-
- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: ELISA, WB, IHC
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For Research Use Only. Not For Clinical Use.