Loading...
DNMT3L
DNMT3L (DNA Methyltransferase 3 Like) is a Protein Coding gene. This gene encodes a nuclear protein with similarity to DNA methyltransferases. It stimulates de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Diseases associated with DNMT3L include Taylor's Syndrome and Testicular Spermatocytic Seminoma.
Protein class
Metabolic proteins, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Proximal tubular cells, Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (BEWO)
Interaction
Homodimer (PubMed:17687327, PubMed:17713477). Heterotetramer composed of 1 DNMT3A homodimer and 2 DNMT3L subunits (DNMT3L-DNMT3A-DNMT3A-DNMT3L) (PubMed:17713477). Interacts with histone H3 (via N-terminus); interaction is strongly inhibited by methylation at lysine 4 (H3K4me) (PubMed:17687327). Interacts with EZH2; the interaction is direct (By similarity). Interacts with SPOCD1 (By similarity).
More Types Infomation
- Mouse Anti-DNMT3L Recombinant Antibody (clone CBS389) (MRO-A1927-YJ)
-
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, ICC, IF
- Mouse Anti-DNMT3L Recombinant Antibody (clone B0-5) (MRO-0489-CN)
-
- Type: Mouse IgG1
- Application: WB, IF, IHC
-
- Species Reactivity: Human
- Application: ICC/IF, IHC-Fr, IHC-P, WB
- Rabbit Anti-DNMT3L Recombinant Antibody (clone rN117/9.5) (VS-0422-LC61)
-
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC
- Human Anti-DNMT3L Recombinant Antibody (clone hN117/9.5) (VS-0422-LC60)
-
- Species Reactivity: Human
- Type: Human IgG1
- Application: WB, IF, IHC
Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us
Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag
For Research Use Only. Not For Clinical Use.