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EBF1
EBF1 (Early B-Cell Factor 1) is a Protein Coding gene. Diseases associated with EBF1 include fetal erythroblastosis and hematologic cancer. Among its related pathways are Developmental Biology and Adipogenesis. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and C2H2 zinc finger domain binding. An important paralog of this gene is EBF2.
Protein class
Cancer-related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Leydig cells, Microglial cells, Smooth muscle cells, Peritubular cells, Fibroblasts, Sertoli cells, Adipocytes)
Immune cell specificity
Group enriched (memory B-cell, naive B-cell)
Cell line specificity
Cell line enhanced (ASC diff, HSkMC, REH, U-2197)
Interaction
Homodimer (PubMed:20592035). Interacts with ZNF423 and ZNF521, leading to prevent EBF1 to bind DNA and activate target genes (PubMed:14630787). Interacts with CCR4-NOT component CNOT3 (PubMed:14630787). (Microbial infection) Interacts with Epstein-barr virus protein EBNA2.
Molecular function
Activator, Developmental protein, DNA-binding
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.