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EHD2
This gene encodes a member of the EH domain-containing protein family. These proteins are characterized by a C-terminal EF-hand domain, a nucleotide-binding consensus site at the N terminus and a bipartite nuclear localization signal. The encoded protein interacts with the actin cytoskeleton through an N-terminal domain and also binds to an EH domain-binding protein through the C-terminal EH domain. This interaction appears to connect clathrin-dependent endocytosis to actin, suggesting that this gene product participates in the endocytic pathway.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Sertoli cells, Adipocytes, Smooth muscle cells, Peritubular cells, Leydig cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, BJ, fHDF/TERT166)
Interaction
Homodimer and homooligomer. Interacts with EHD1. May also interact with EHD3 and EHD4 (PubMed:17233914). Interacts with MYOF (PubMed:18502764). Interacts with EHBP1. Interacts with FER1L5 (via second C2 domain) (By similarity). Interacts with CAV1 in a cholesterol-dependent manner (PubMed:25588833). Interacts (via EH domain) with PACSIN2 (via NPF motifs); this interaction probably stabilizes the caveolae (PubMed:22323287).
Molecular function
Hydrolase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Mouse, Rat, Human
- Type: Rabbit IgG
- Application: WB, ICC, IF
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For Research Use Only. Not For Clinical Use.