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EIF2AK4
This gene encodes a member of a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2), resulting in the downregulaton of protein synthesis. The encoded protein responds to amino acid deprivation by binding uncharged transfer RNAs. It may also be activated by glucose deprivation and viral infection. Mutations in this gene have been found in individuals suffering from autosomal recessive pulmonary venoocclusive-disease-2.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Low cell line specificity
Interaction
Homodimer; homodimerization is important for kinase activation by uncharged tRNAs. Interacts with GCN1; this interaction stimulates EIF2AK4/GCN2 kinase activity and is impaired by IMPACT upon a variety of stress conditions, such as amino acid depletion, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Interacts with DNAJC3; this interaction inhibits EIF2AK4/GCN2 kinase activity during endoplasmic reticulum (ER), hypothermic and amino acid-starving stress conditions.
Molecular function
Activator, Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, tRNA-binding
More Types Infomation
- Rabbit Anti-EIF2AK4 Recombinant Antibody (clone JA03-83) (MRO-0642-CN)
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- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IF, IHC, FC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: IP, WB
- Chicken Anti-GCN2 Polyclonal IgY (BRD-0753MZ)
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- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: ELISA, IF, IHC, IP, WB
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For Research Use Only. Not For Clinical Use.