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ELN
This gene encodes a protein that is one of the two components of elastic fibers. Elastic fibers comprise part of the extracellular matrix and confer elasticity to organs and tissues including the heart, skin, lungs, ligaments, and blood vessels. The encoded protein is rich in hydrophobic amino acids such as glycine and proline, which form mobile hydrophobic regions bounded by crosslinks between lysine residues. Degradation products of the encoded protein, known as elastin-derived peptides or elastokines, bind the elastin receptor complex and other receptors and stimulate migration and proliferation of monocytes and skin fibroblasts. Elastokines can also contribute to cancer progression. Deletions and mutations in this gene are associated with supravalvular aortic stenosis (SVAS) and autosomal dominant cutis laxa. [provided by RefSeq, Aug 2017]
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Peritubular cells, Fibroblasts, Leydig cells, Endometrial stromal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (ASC diff, BJ, fHDF/TERT166, U-2197)
Interaction
The polymeric elastin chains are cross-linked together into an extensible 3D network. Forms a ternary complex with BGN and MFAP2. Interacts with MFAP2 via divalent cations (calcium> magnesium> manganese) in a dose-dependent and saturating manner. Interacts with FBLN5 (PubMed:15790312, PubMed:17035250). Interacts with FBN1 (PubMed:15790312). Forms a ternary complex with FBN1 and FBLN2 or FBLN5 (PubMed:17255108). Interacts with MFAP4 in a Ca (2+)-dependent manner; this interaction promotes ELN self-assembly (By similarity) (PubMed:15790312, PubMed:17035250, PubMed:17255108). Interacts with EFEMP2 with moderate affinity (PubMed:16478991).
More Types Infomation
- PE-A*02:05/Human Elastin (GVLGGLGAL) MHC Tetramer (MHC-CN0106)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GVLGGLGAL
- Conjugate: PE
- APC-A*02:05/Human Elastin (GVLGGLGAL) MHC Tetramer (MHC-CN0105)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GVLGGLGAL
- Conjugate: APC
- PE-A*02:01/Human Elastin (GVGAGVPGL) MHC Tetramer (MHC-CN0104)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GVGAGVPGL
- Conjugate: PE
- APC-A*02:01/Human Elastin (GVGAGVPGL) MHC Tetramer (MHC-CN0103)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GVGAGVPGL
- Conjugate: APC
- PE-A*02:01/Human Elastin (GLGVGGLGV) MHC Tetramer (MHC-CN0096)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GLGVGGLGV
- Conjugate: PE
- APC-A*02:01/Human Elastin (GLGVGGLGV) MHC Tetramer (MHC-CN0095)
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: GLGVGGLGV
- Conjugate: APC
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: ARFPGVGVL
- Conjugate: PE
-
- Class: Class I
- Antigen: Elastin
- Antigen Species: Human
- Peptide: ARFPGVGVL
- Conjugate: APC
-
- Species Reactivity: Human, Mouse, Rat, Bovine, Canine, Porcine, Cat
- Type: Mouse IgG1, κ
- Application: WB, IP, IHC-P, IF
-
- Species Reactivity: Human
- Application: ELISA, ICC, IHC-Fr, IHC-P, IP, WB
- Mouse Anti-ELN Recombinant Antibody (clone 24C9) (MOB-1461z)
-
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IHC
- Guinea Pig Anti-ELN Antibody (ZG-0660F) (ZG-0660F)
-
- Species Reactivity: Human
- Application: IF, IHC-P, ELISA, RIA
- Guinea Pig Anti-ELN Antibody (ZG-0659F) (ZG-0659F)
-
- Species Reactivity: Human
- Application: IF, IHC-P, ELISA, RIA
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For Research Use Only. Not For Clinical Use.