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ERCC4
The protein encoded by this gene forms a complex with ERCC1 and is involved in the 5 incision made during nucleotide excision repair. This complex is a structure specific DNA repair endonuclease that interacts with EME1. Defects in this gene are a cause of xeroderma pigmentosum complementation group F (XP-F), or xeroderma pigmentosum VI (XP6).[provided by RefSeq, Mar 2009]
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Late spermatids)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Heterodimer composed of ERCC1 and ERCC4/XPF (PubMed:10413517, PubMed:25538220, PubMed:32034146, PubMed:16076955, PubMed:16338413). Interacts with SLX4/BTBD12; this interaction is direct and links the ERCC1-ERCC4/XPF complex to SLX4, which may coordinate the action of the structure-specific endonuclease during DNA repair (PubMed:19596235, PubMed:19596236, PubMed:25538220, PubMed:19595721, PubMed:19595722).
Molecular function
DNA-binding, Endonuclease, Hydrolase, Nuclease
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA, ICC/IF, IHC-P, WB
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For Research Use Only. Not For Clinical Use.