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GATA4
This gene encodes a member of the GATA family of zinc-finger transcription factors. Members of this family recognize the GATA motif which is present in the promoters of many genes. This protein is thought to regulate genes involved in embryogenesis and in myocardial differentiation and function, and is necessary for normal testicular development. Mutations in this gene have been associated with cardiac septal defects. Additionally, alterations in gene expression have been associated with several cancer types. Alternative splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells, Theca cells, Gastric mucus-secreting cells, Hepatic stellate cells, Cardiomyocytes, Peritubular cells, Leydig cells, Late spermatids, Exocrine glandular cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (Hep G2, HHSteC, OE19, SH-SY5Y)
Interaction
Interacts with ZNF260 (By similarity). Interacts with the homeobox domain of NKX2-5 through its C-terminal zinc finger. Also interacts with JARID2 which represses its ability to activate transcription of ANF. Interacts (via the second Zn finger) with NFATC4 (By similarity). Interacts with LMCD1 (By similarity). Forms a complex made of CDK9, CCNT1/cyclin-T1, EP300 and GATA4 that stimulates hypertrophy in cardiomyocytes. Interacts with NR5A1, ZFPM2 and TBX5. Interacts with TBX18.
Molecular function
Activator, DNA-binding
More Types Infomation
- Rabbit Anti-GATA4 Polyclonal Antibody (MRO-1886-CN) (MRO-1886-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, FC
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: WB, IP, IF, IHC, ELISA
- Rabbit Anti-GATA4 Recombinant Antibody (clone JA11-41) (MRO-0638-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, FC
- Mouse Anti-GATA4 Recombinant Antibody (clone 7-4) (MRO-0637-CN)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, ICC, FC
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- Species Reactivity: Human
- Application: WB, ELISA
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- Species Reactivity: Human, Mouse
- Type: Mouse IgG
- Application: WB, ELISA
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- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: ELISA, WB
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For Research Use Only. Not For Clinical Use.