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GCLC
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Urothelial cells)
Immune cell specificity
Immune cell enhanced (NK-cell)
Cell line specificity
Cell line enhanced (A549, Hep G2, OE19, RT4)
Interaction
Heterodimer of a catalytic heavy chain and a regulatory light chain.
Molecular function
Ligase
More Types Infomation
- Rabbit Anti-GCLC Recombinant Antibody (clone JA08-03) (MRO-0640-CN)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB, IHC, FC
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- Derivation: Phage display library
- Species Reactivity: Rat, Human
- Type: Rabbit IgG
- Application: WB
- Recombinant Mouse Anti-Human GCLC Antibody (MOB-1995MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
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- Species Reactivity: Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IP
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB
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For Research Use Only. Not For Clinical Use.